SCHEMBL17615320

SCHEMBL17615320

CC(C)OC(=O)[C@H](C)N[P@]1(=O)OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@](C)(Cl)[C@@H]2O1

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ STING1 Q86WV6 13/20 0.47
▸ AHCY P23526 1/20 0.42
▸ LMNA P02545 2/20 0.41
▸ RAPGEF3 O95398 2/20 0.41
▸ GMNN O75496 1/20 0.41
▸ BLM P54132 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ RAPGEF4 Q8WZA2 1/20 0.41
▸ RXFP1 Q9HBX9 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16480794 1.00 STING1 (0.47) STING1AHCYLMNARAPGEF3GMNN
SCHEMBL15588438 1.00 STING1 (0.47) STING1AHCYLMNARAPGEF3GMNN
SCHEMBL16480782 1.00 STING1 (0.47) STING1AHCYLMNARAPGEF3GMNN
SCHEMBL16480800 1.00 STING1 (0.47) STING1AHCYLMNARAPGEF3GMNN
SCHEMBL15588449 1.00 STING1 (0.47) STING1AHCYLMNARAPGEF3GMNN
SCHEMBL15588731 1.00 STING1 (0.47) STING1AHCYLMNARAPGEF3GMNN
SCHEMBL17403964 0.89 STING1 (0.36) STING1AHCYRXFP1
SCHEMBL16480802 0.87 STING1 (0.43) STING1LMNARAPGEF3GMNNBLM
SCHEMBL16480779 0.87 STING1 (0.43) STING1LMNARAPGEF3GMNNBLM
SCHEMBL16480784 0.87 STING1 (0.43) STING1LMNARAPGEF3GMNNBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160083413-A1 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION IDENIX PHARMACEUTICALS LLC 2016-03-24 — — US disclosed
US-20160083413-A1 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION IDENIX PHARMACEUTICALS LLC 2016-03-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160083413-A1 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION SLC28A2, SLC28A1, SLC29A2 STING1 812/4885AHCY 1017/4885LMNA 1863/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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