Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15805401 | 0.92 | PTPN11 (0.44) | PTPN11SLC1A3SLC1A2SLC1A1PDGFRB | |
| SCHEMBL15805407 | 0.88 | PTPN11 (0.50) | PTPN11SLC1A3SLC1A2SLC1A1PDGFRB | |
| SCHEMBL15805357 | 0.85 | PTPN11 (0.46) | PTPN11SLC1A3SLC1A2SLC1A1PDGFRB | |
| SCHEMBL15805406 | 0.83 | PTPN11 (0.46) | PTPN11SLC1A3SLC1A2SLC1A1PDGFRB | |
| SCHEMBL15805426 | 0.83 | PTPN11 (0.46) | PTPN11SLC1A3SLC1A2SLC1A1PDGFRB | |
| SCHEMBL15805403 | 0.82 | PTPN11 (0.43) | PTPN11SLC1A3SLC1A2SLC1A1PDGFRB | |
| SCHEMBL15805188 | 0.82 | PTPN11 (0.43) | PTPN11SLC1A3SLC1A2SLC1A1PDGFRB | |
| SCHEMBL15805355 | 0.81 | PTPN11 (0.48) | PTPN11SLC1A3SLC1A2SLC1A1PDGFRB | |
| SCHEMBL17636888 | 0.80 | PTPN11 (0.44) | PTPN11BRD4PIM1PIM2L3MBTL1 | |
| SCHEMBL15805344 | 0.80 | PTPN11 (0.45) | PTPN11SLC1A3SLC1A2SLC1A1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160081989-A1 | Substituted 1 H-Pyrrolo [2, 3-b] pyridine and 1 H-Pyrazolo [3, 4-b] pyridine Derivatives as Salt Inducible Kinase 2 (SIK2) Inhibitors | ARRIEN PHARMACEUTICALS LLC | 2016-03-24 | — | — | US | disclosed |
| US-20160081989-A1 | Substituted 1 H-Pyrrolo [2, 3-b] pyridine and 1 H-Pyrazolo [3, 4-b] pyridine Derivatives as Salt Inducible Kinase 2 (SIK2) Inhibitors | ARRIEN PHARMACEUTICALS LLC | 2016-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160081989-A1 | Substituted 1 H-Pyrrolo [2, 3-b] pyridine and 1 H-Pyrazolo [3, 4-b] pyridine Derivatives as Salt Inducible Kinase 2 (SIK2) Inhibitors | SIK2, SIK1, SIK3 | PTPN11 508/4885SLC1A3 3794/4885SLC1A2 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.