Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17561 | 1.00 | GCKR (0.85) | GCKRGCK | |
| SCHEMBL16768 | 1.00 | GCKR (0.85) | GCKRGCK | |
| Trifluoroacetic Acid SCHEMBL12078254 | 0.96 | GCKR (0.79) | GCKRGCK | |
| Trifluoroacetic Acid SCHEMBL12078953 | 0.96 | GCKR (0.79) | GCKRGCK | |
| Trifluoroacetic Acid SCHEMBL12078468 | 0.96 | GCKR (0.79) | GCKRGCK | |
| Trifluoroacetic Acid SCHEMBL16763 | 0.96 | GCKR (0.79) | GCKRGCK | |
| Trifluoroacetic Acid SCHEMBL12079101 | 0.96 | GCKR (0.79) | GCKRGCK | |
| Trifluoroacetic Acid SCHEMBL16889 | 0.96 | GCKR (0.79) | GCKRGCK | |
| Trifluoroacetic Acid SCHEMBL17038 | 0.96 | GCKR (0.79) | GCKRGCK | |
| SCHEMBL16547 | 0.93 | GCKR (0.85) | GCKRGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120225854-A1 | COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-09-06 | — | — | US | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225854-A1 | COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | GCKR, GCK, SLC5A2 | GCKR 1/4885GCK 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.