Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17619475 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 | |
| SCHEMBL10130029 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 | |
| SCHEMBL17610275 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 | |
| SCHEMBL1189348 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 | |
| SCHEMBL15218647 | 0.91 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 | |
| SCHEMBL16472423 | 0.91 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 | |
| SCHEMBL15883697 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 | |
| SCHEMBL30232243 | 0.90 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 | |
| SCHEMBL2621382 | 0.90 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 | |
| SCHEMBL2621378 | 0.90 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9AHTR2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044666-A1 | HETEROCYCLE SUBSTITUTED AMINO-PYRIDINE COMPOUNDS AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2016-03-24 | — | — | WO | disclosed |