Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 17/20 | 0.50 |
| ▸ | CTSD | P07339 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17620300 | 1.00 | BACE1 (0.50) | BACE1CTSDADORA2A | |
| SCHEMBL17620340 | 0.81 | BACE1 (0.54) | BACE1CTSD | |
| SCHEMBL17620341 | 0.81 | BACE1 (0.54) | BACE1CTSD | |
| SCHEMBL17620294 | 0.81 | BACE1 (0.62) | BACE1CTSD | |
| SCHEMBL17620367 | 0.77 | BACE1 (0.61) | BACE1CTSD | |
| SCHEMBL17620310 | 0.73 | BACE1 (0.77) | BACE1CTSD | |
| SCHEMBL17620318 | 0.72 | BACE1 (0.61) | BACE1CTSD | |
| SCHEMBL17620317 | 0.72 | BACE1 (0.61) | BACE1CTSD | |
| SCHEMBL17620353 | 0.71 | BACE1 (0.74) | BACE1CTSD | |
| SCHEMBL17620355 | 0.71 | BACE1 (0.74) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296698-B2 | Amino heteroaryl compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2016-03-29 | — | — | US | claimed |