Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.79 |
| ▸ | CTSD | P07339 | 4/20 | 0.53 |
| ▸ | PANK1 | Q8TE04 | 1/20 | 0.46 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17620296 | 0.89 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL17620310 | 0.88 | BACE1 (0.77) | BACE1CTSDPANK1PANK3ENPP2 | |
| SCHEMBL17620344 | 0.87 | BACE1 (0.80) | BACE1CTSD | |
| SCHEMBL17620285 | 0.87 | BACE1 (0.83) | BACE1CTSD | |
| SCHEMBL17620346 | 0.85 | BACE1 (0.81) | BACE1CTSD | |
| SCHEMBL13871 | 0.85 | BACE1 (0.80) | BACE1CTSDENPP2 | |
| SCHEMBL17620306 | 0.84 | BACE1 (0.79) | BACE1CTSD | |
| SCHEMBL17620342 | 0.84 | BACE1 (0.79) | BACE1CTSD | |
| SCHEMBL17620357 | 0.84 | BACE1 (0.78) | BACE1CTSDENPP2 | |
| SCHEMBL17620307 | 0.83 | BACE1 (0.69) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296698-B2 | Amino heteroaryl compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2016-03-29 | — | — | US | claimed |