Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.76 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9959 | 0.92 | BACE1 (0.76) | BACE1CTSD | |
| SCHEMBL17620279 | 0.90 | BACE1 (0.73) | BACE1 | |
| SCHEMBL8662 | 0.88 | BACE1 (0.75) | BACE1CTSD | |
| SCHEMBL8794 | 0.86 | BACE1 (1.00) | BACE1 | |
| SCHEMBL9516 | 0.85 | BACE1 (0.84) | BACE1CTSD | |
| SCHEMBL9232 | 0.84 | BACE1 (0.79) | BACE1CTSD | |
| SCHEMBL14322038 | 0.84 | BACE1 (0.81) | BACE1 | |
| SCHEMBL10147 | 0.82 | BACE1 (0.75) | BACE1 | |
| SCHEMBL8957 | 0.82 | BACE1 (0.77) | BACE1 | |
| SCHEMBL9071 | 0.80 | BACE1 (0.72) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296698-B2 | Amino heteroaryl compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2016-03-29 | — | — | US | claimed |