Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.68 |
| ▸ | CTSD | P07339 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630 | 0.81 | BACE1 (0.84) | BACE1CTSD | |
| SCHEMBL17620296 | 0.81 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL9058 | 0.80 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL17620360 | 0.78 | BACE1 (0.77) | BACE1CTSD | |
| SCHEMBL9829 | 0.78 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL17620354 | 0.77 | BACE1 (0.78) | BACE1CTSD | |
| SCHEMBL9288 | 0.76 | BACE1 (1.00) | BACE1CTSD | |
| SCHEMBL17620324 | 0.76 | BACE1 (0.78) | BACE1CTSD | |
| SCHEMBL17620365 | 0.76 | BACE1 (0.77) | BACE1CTSD | |
| SCHEMBL17620371 | 0.75 | BACE1 (1.00) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296698-B2 | Amino heteroaryl compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2016-03-29 | — | — | US | claimed |