Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 3/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17643345 | 0.87 | KRAS (0.52) | GAAKRASSHMT2ALDH1A1SCD | |
| SCHEMBL16122668 | 0.86 | KRAS (0.60) | GAAKRASSHMT2 | |
| SCHEMBL16122573 | 0.85 | KRAS (0.46) | GAAKRASSHMT2ALDH1A1SCD | |
| SCHEMBL16122675 | 0.85 | KRAS (0.44) | GAAKRASSHMT2 | |
| SCHEMBL21302146 | 0.83 | KRAS (0.46) | GAAKRASSHMT2MEN1KMT2A | |
| SCHEMBL16129117 | 0.76 | SMN1; SMN2 (0.39) | ALDH1A1CYP3A4CYP2C19MEN1KMT2A | |
| SCHEMBL16102313 | 0.75 | KRAS (0.46) | GAAKRASSHMT2CYP3A4CYP2C19 | |
| SCHEMBL20260100 | 0.75 | KRAS (0.55) | KRASALDH1A1MEN1KMT2A | |
| SCHEMBL16122893 | 0.75 | KRAS (0.65) | GAAKRASSHMT2CYP3A4CYP2C19 | |
| SCHEMBL17643505 | 0.73 | KRAS (0.69) | GAAKRASSCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016044772-A1 | COMBINATION THERAPIES FOR TREATMENT OF CANCER | ARAXES PHARMA LLC (US) | 2016-03-24 | — | — | WO | disclosed |