Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 2/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2068503 | 0.91 | KCNH2 (0.57) | KCNH2CYP3A4P2RX7 | |
| SCHEMBL17626302 | 0.87 | KCNH2 (0.59) | KCNH2CYP3A4DPP4CSNK1DCSNK1E | |
| SCHEMBL17626363 | 0.86 | KCNH2 (0.61) | KCNH2CYP3A4DPP4CSNK1DCSNK1E | |
| SCHEMBL2067500 | 0.86 | KCNH2 (0.65) | KCNH2CYP3A4P2RX7 | |
| SCHEMBL17626373 | 0.85 | KCNH2 (0.60) | KCNH2CYP3A4FPR1FPR2 | |
| SCHEMBL12952019 | 0.84 | KCNH2 (0.71) | KCNH2CYP3A4DPP4 | |
| SCHEMBL17626542 | 0.84 | KCNH2 (0.59) | KCNH2CYP3A4P2RX7FPR1FPR2 | |
| SCHEMBL2068235 | 0.82 | KCNH2 (0.67) | KCNH2CYP3A4DPP4CSNK1DCSNK1E | |
| SCHEMBL2068435 | 0.82 | KCNH2 (0.67) | KCNH2CYP3A4DPP4CSNK1DCSNK1E | |
| SCHEMBL12845806 | 0.82 | KCNH2 (0.67) | KCNH2CYP3A4DPP4CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2737927-B1 | Imidazo[1,2a]pyrazines and compositions comprising them for the treatment of parasitic diseases | NOVARTIS AG (CH) | 2016-03-30 | — | — | EP | claimed |