Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 17/20 | 0.72 |
| ▸ | EGLN2 | Q96KS0 | 14/20 | 0.72 |
| ▸ | EGLN3 | Q9H6Z9 | 14/20 | 0.72 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17629658 | 0.98 | EGLN1 (0.69) | EGLN1EGLN2EGLN3CYSLTR2MEN1 | |
| SCHEMBL17629630 | 0.93 | EGLN1 (0.72) | EGLN1EGLN2EGLN3CYSLTR2MEN1 | |
| SCHEMBL17629576 | 0.84 | EGLN1 (0.78) | EGLN1EGLN2EGLN3CYSLTR2MEN1 | |
| SCHEMBL17629571 | 0.84 | EGLN1 (1.00) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL20258261 | 0.82 | EGLN1 (0.73) | EGLN1EGLN2EGLN3CYSLTR2MEN1 | |
| SCHEMBL17633231 | 0.82 | EGLN1 (0.73) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633230 | 0.82 | EGLN1 (0.73) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17629654 | 0.82 | EGLN1 (0.80) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17629642 | 0.82 | EGLN1 (0.74) | EGLN1EGLN2EGLN3CYSLTR2ALDH1A1 | |
| SCHEMBL17629619 | 0.81 | EGLN1 (0.95) | EGLN1EGLN2EGLN3CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197455-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049097-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |