Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 15/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 14/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28383178 | 1.00 | GRIN2B (0.58) | GRIN2BGRIN1RIPK1MGLLHSD11B1 | |
| SCHEMBL17633359 | 1.00 | GRIN2B (0.58) | GRIN2BGRIN1RIPK1MGLLHSD11B1 | |
| SCHEMBL17633278 | 1.00 | GRIN2B (0.58) | GRIN2BGRIN1RIPK1MGLLHSD11B1 | |
| SCHEMBL29471127 | 0.82 | GRIN1 (0.55) | GRIN2BGRIN1 | |
| SCHEMBL17643339 | 0.82 | GRIN1 (0.55) | GRIN2BGRIN1 | |
| SCHEMBL15641032 | 0.81 | USP30 (0.50) | GRIN2BGRIN1 | |
| SCHEMBL15641030 | 0.81 | USP30 (0.50) | GRIN2BGRIN1 | |
| SCHEMBL17633323 | 0.80 | GRIN1 (0.56) | GRIN2BGRIN1RIPK1MGLL | |
| SCHEMBL17633327 | 0.80 | GRIN1 (0.56) | GRIN2BGRIN1RIPK1MGLL | |
| SCHEMBL27076410 | 0.80 | GRIN1 (0.56) | GRIN2BGRIN1RIPK1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106795111-B | N-alkylaryl-5-oxyaryl-octahydro-cyclopenta [ C ] pyrroles as negative allosteric modulators of NR2B | 科登特治疗公司 | 2020-04-07 | — | — | CN | disclosed |
| EP-3197868-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | Luc Therapeutics, Inc. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049165-A1 | N-ALKYLARYL-5-OXYARYL-OCTAHYDRO-CYCLOPENTA[C]PYRROLE NEGATIVE ALLOSTERIC MODULATORS OF NR2B | MNEMOSYNE PHARMACEUTICALS, INC. (US) | 2016-03-31 | — | — | WO | disclosed |