Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 20/20 | 0.62 |
| ▸ | EGLN2 | Q96KS0 | 18/20 | 0.62 |
| ▸ | EGLN3 | Q9H6Z9 | 18/20 | 0.62 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17633316 | 0.89 | EGLN1 (0.62) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633380 | 0.89 | EGLN1 (0.61) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL3775376 | 0.88 | EGLN1 (0.79) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL13017097 | 0.87 | EGLN1 (0.66) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL12917891 | 0.87 | EGLN1 (0.46) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633128 | 0.86 | EGLN1 (0.68) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633387 | 0.86 | EGLN1 (0.82) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL3773677 | 0.85 | EGLN1 (0.79) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633265 | 0.85 | EGLN1 (0.64) | EGLN1EGLN2EGLN3CYSLTR2 | |
| SCHEMBL17633107 | 0.85 | EGLN1 (0.63) | EGLN1EGLN2EGLN3CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197451-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049100-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |