Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 18/20 | 0.86 |
| ▸ | CSF1R | P07333 | 17/20 | 0.86 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.83 |
| ▸ | KIT | P10721 | 4/20 | 0.83 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.83 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12069008 | 0.93 | FLT3 (0.86) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698768 | 0.92 | FLT3 (1.00) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698609 | 0.92 | FLT3 (1.00) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698611 | 0.91 | FLT3 (1.00) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698696 | 0.91 | FLT3 (1.00) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698671 | 0.91 | FLT3 (0.81) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698597 | 0.89 | FLT3 (0.94) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL17634384 | 0.89 | FLT3 (0.83) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL12067858 | 0.89 | FLT3 (1.00) | FLT3CSF1RPDGFRBKITPDGFRA | |
| SCHEMBL1698581 | 0.89 | FLT3 (1.00) | FLT3CSF1RPDGFRBKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296722-B2 | Azolyl urea compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2016-03-29 | — | — | US | disclosed |