Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.62 |
| ▸ | APP | P05067 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10156225 | 0.90 | BACE1 (0.66) | BACE1APPKCNH2 | |
| SCHEMBL10157601 | 0.86 | BACE1 (0.62) | BACE1APPKCNH2 | |
| SCHEMBL10155131 | 0.85 | BACE1 (0.80) | BACE1APP | |
| SCHEMBL10154574 | 0.85 | BACE1 (0.59) | BACE1APPKCNH2 | |
| SCHEMBL10157123 | 0.85 | BACE1 (0.59) | BACE1APPKCNH2 | |
| SCHEMBL10157884 | 0.85 | BACE1 (0.76) | BACE1APP | |
| SCHEMBL10154943 | 0.84 | BACE1 (0.55) | BACE1APPKCNH2 | |
| SCHEMBL15041116 | 0.84 | BACE1 (0.64) | BACE1KCNH2 | |
| SCHEMBL10154673 | 0.83 | BACE1 (0.64) | BACE1APPKCNH2 | |
| SCHEMBL10267051 | 0.83 | BACE1 (0.67) | BACE1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597087-B1 | Dihydrooxazine and tetrahydropyrimidine derivatives as BACE 1 inhibitors | SHIONOGI & CO (JP) | 2016-03-30 | — | — | EP | disclosed |