Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16324583 | 0.91 | HTT (0.67) | HSD11B1USP2TP53HTTSMN1; SMN2 | |
| SCHEMBL31390332 | 0.90 | HTT (0.62) | HSD11B1USP2TP53HTTSMN1; SMN2 | |
| SCHEMBL14856225 | 0.90 | HTT (0.62) | HSD11B1USP2TP53HTTSMN1; SMN2 | |
| SCHEMBL16323195 | 0.85 | NPC1 (0.80) | HSD11B1USP2TP53HTTSMN1; SMN2 | |
| SCHEMBL14856214 | 0.85 | POLB (0.63) | HSD11B1USP2TP53HTTSMN1; SMN2 | |
| SCHEMBL17637165 | 0.85 | USP2 (0.58) | HSD11B1USP2TP53HTTSMN1; SMN2 | |
| SCHEMBL150915 | 0.85 | NPC1 (0.68) | USP2TP53HTTSMN1; SMN2LMNA | |
| SCHEMBL28589540 | 0.85 | USP2 (0.73) | USP2TP53HTTSMN1; SMN2LMNA | |
| SCHEMBL29586454 | 0.85 | NPC1 (0.68) | USP2TP53HTTSMN1; SMN2LMNA | |
| SCHEMBL4838604 | 0.85 | USP2 (0.73) | USP2TP53HTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9655880-B2 | Azetidine estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-9655880-B2 | Azetidine estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2017-05-23 | — | — | US | disclosed |
| US-20160367526-A1 | AZETIDINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-12-22 | — | — | US | disclosed |
| US-9475798-B2 | Azetidine estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2016-10-25 | — | — | US | disclosed |
| US-20160175284-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-23 | — | — | US | disclosed |
| US-20160090377-A1 | AZETIDINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160090377-A1 | AZETIDINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ESR1, ESR2, GPER1 | HSD11B1 775/4885USP2 896/4885TP53 1326/4885 |
| US-20160367526-A1 | AZETIDINE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ESR1, ESR2, GPER1 | HSD11B1 775/4885USP2 896/4885TP53 1326/4885 |
| US-20160175284-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | ESR2, GPER1, ESR1 | HSD11B1 81/4885USP2 1915/4885TP53 1522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.