Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | AKT1 | P31749 | 3/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.40 |
| ▸ | PRKACA | P17612 | 3/20 | 0.40 |
| ▸ | CDK8 | P49336 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17640596 | 1.00 | PIK3CD (0.56) | PIK3CDPIK3CGAKT1AKT2MAP4K4 | |
| SCHEMBL20964203 | 1.00 | PIK3CD (0.56) | PIK3CDPIK3CGAKT1AKT2MAP4K4 | |
| Hydrochloric Acid SCHEMBL25322360 | 0.99 | PIK3CD (0.55) | PIK3CDPIK3CGAKT1AKT2MAP4K4 | |
| Hydrochloric Acid SCHEMBL25322357 | 0.99 | PIK3CD (0.55) | PIK3CDPIK3CGAKT1AKT2MAP4K4 | |
| SCHEMBL17640685 | 0.89 | DYRK1A (0.47) | PIK3CDPIK3CGAKT1AKT2MAP4K4 | |
| SCHEMBL17640714 | 0.87 | PIK3CD (0.45) | PIK3CDPIK3CGAKT1AKT2MAP4K4 | |
| SCHEMBL17640722 | 0.87 | PIK3CD (0.45) | PIK3CDPIK3CGAKT1AKT2MAP4K4 | |
| SCHEMBL19322410 | 0.87 | PIK3CD (0.53) | PIK3CDPIK3CGAKT1AKT2MAP4K4 | |
| SCHEMBL17640716 | 0.87 | PIK3CD (0.45) | PIK3CDPIK3CGAKT1AKT2KDR | |
| SCHEMBL17640717 | 0.86 | PIK3CD (0.44) | PIK3CDPIK3CGAKT1AKT2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611777-B2 | Imidazopyridazine compounds and their use | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-04-07 | — | — | US | disclosed |
| US-10611777-B2 | Imidazopyridazine compounds and their use | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-04-07 | — | — | US | disclosed |
| US-20190127391-A1 | NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LTD (CN) | 2019-05-02 | — | — | US | disclosed |
| US-20190127391-A1 | NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LTD (CN) | 2019-05-02 | — | — | US | disclosed |
| US-10208066-B2 | Imidazopyridazine compounds and their use | HUTCHISON MEDIPHARMA LIMITED (CN) | 2019-02-19 | — | — | US | disclosed |
| US-10208066-B2 | Imidazopyridazine compounds and their use | HUTCHISON MEDIPHARMA LIMITED (CN) | 2019-02-19 | — | — | US | disclosed |
| US-20170253618-A1 | NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2017-09-07 | — | — | US | disclosed |
| US-20170253618-A1 | NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2017-09-07 | — | — | US | disclosed |
| US-20170253618-A1 | NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2017-09-07 | — | — | US | disclosed |
| WO-2016045591-A1 | NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2016-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253618-A1 | NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE | PIK3R5, PIK3CD, PIK3CB | PIK3CD 2/4885PIK3CG 9/4885AKT1 86/4885 |
| US-10208066-B2 | Imidazopyridazine compounds and their use | PIK3R5, PIK3CD, INPP5D | PIK3CD 2/4885PIK3CG 8/4885AKT1 103/4885 |
| US-20190127391-A1 | NOVEL IMIDAZOPYRIDAZINE COMPOUNDS AND THEIR USE | PIK3R5, PIK3CD, PIK3CB | PIK3CD 2/4885PIK3CG 9/4885AKT1 86/4885 |
| US-10611777-B2 | Imidazopyridazine compounds and their use | PIK3R5, PIK3CD, INPP5D | PIK3CD 2/4885PIK3CG 8/4885AKT1 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.