Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | ATM | Q13315 | 1/20 | 0.75 |
| ▸ | PPP1CA | P62136 | 4/20 | 0.72 |
| ▸ | RPA1 | P27694 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | MARS1 | P56192 | 2/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1765047 | 0.91 | PPP1CA (0.78) | KMT2AMEN1ATMPPP1CARPA1 | |
| SCHEMBL1764890 | 0.88 | KMT2A (0.82) | KMT2AMEN1ATMPPP1CARPA1 | |
| SCHEMBL1765063 | 0.88 | PPP1CA (0.82) | KMT2AMEN1ATMPPP1CARPA1 | |
| SCHEMBL1765048 | 0.88 | KMT2A (0.75) | KMT2AMEN1ATMPPP1CARPA1 | |
| SCHEMBL1514409 | 0.87 | KMT2A (1.00) | KMT2AMEN1ATMPPP1CARPA1 | |
| SCHEMBL4493013 | 0.86 | KMT2A (1.00) | KMT2AMEN1ATMPPP1CARPA1 | |
| SCHEMBL1765012 | 0.84 | PPP1CA (0.71) | KMT2AMEN1ATMPPP1CARPA1 | |
| SCHEMBL1765493 | 0.84 | PPP1CA (0.74) | KMT2AMEN1ATMPPP1CARPA1 | |
| SCHEMBL1765418 | 0.83 | CHRNA7 (0.64) | KMT2AMEN1ATMPPP1CAPTGS1 | |
| SCHEMBL1765546 | 0.83 | PPP1CA (0.60) | KMT2AMEN1ATMPPP1CARPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101977908-B | (pyrazolyl carbonyl) imidazolidinone derivatives for the treatment of retroviral diseases | AICURIS GMBH & CO KG | 2014-04-23 | — | — | CN | disclosed |
| US-8399682-B2 | Substituted (pyrazolylcarbonyl)imidazolidinones and their use | AICURIS GMBH & CO. KG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8399682-B2 | Substituted (pyrazolylcarbonyl)imidazolidinones and their use | AICURIS GMBH & CO. KG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8399682-B2 | Substituted (pyrazolylcarbonyl)imidazolidinones and their use | AICURIS GMBH & CO. KG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-20110124618-A1 | SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE | AICURIS GMBH & CO. KG (DE) | 2011-05-26 | — | — | US | disclosed |
| US-20110124618-A1 | SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE | AICURIS GMBH & CO. KG (DE) | 2011-05-26 | — | — | US | disclosed |
| US-20110124618-A1 | SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE | AICURIS GMBH & CO. KG (DE) | 2011-05-26 | — | — | US | disclosed |
| CN-101977908-A | (pyrazolyl carbonyl) imidazolidinone derivatives for the treatment of retroviral diseases | AICURIS GMBH & CO KG | 2011-02-16 | — | — | CN | disclosed |
| EP-2254885-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124618-A1 | SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE | TPMT, PAICS, THPO | KMT2A 1193/4885MEN1 2360/4885ATM 2849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.