Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 14/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653250 | 0.89 | AAK1 (0.55) | AAK1CHEK1GSK3BMKNK1BMP2K | |
| SCHEMBL17653186 | 0.86 | AAK1 (0.52) | AAK1 | |
| SCHEMBL17653269 | 0.86 | AAK1 (0.42) | AAK1CHEK1GSK3BMKNK1BMP2K | |
| SCHEMBL17653264 | 0.82 | AAK1 (0.40) | AAK1GSK3BF2PDPK1 | |
| SCHEMBL17653295 | 0.81 | AAK1 (0.52) | AAK1CHEK1GSK3BMKNK1BMP2K | |
| SCHEMBL16974282 | 0.79 | AAK1 (0.42) | AAK1CHEK1GSK3BMKNK1BMP2K | |
| SCHEMBL17653231 | 0.75 | AAK1 (0.58) | AAK1 | |
| SCHEMBL17653203 | 0.75 | AAK1 (0.47) | AAK1CHEK1GSK3BMKNK1BMP2K | |
| SCHEMBL17653114 | 0.74 | AAK1 (0.41) | AAK1 | |
| SCHEMBL17653261 | 0.74 | AAK1 (0.38) | AAK1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200797-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016053794-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-07 | — | — | WO | disclosed |