Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 15/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653401 | 0.85 | AAK1 (0.57) | AAK1ABL1IRAK4SLC10A2BRAF | |
| SCHEMBL17653135 | 0.81 | AAK1 (1.00) | AAK1 | |
| SCHEMBL17653362 | 0.80 | AAK1 (0.65) | AAK1SLC10A2 | |
| SCHEMBL17663459 | 0.80 | AAK1 (0.69) | AAK1 | |
| SCHEMBL16974260 | 0.76 | AAK1 (0.65) | AAK1ABL1SLC10A2BRAF | |
| SCHEMBL17653133 | 0.76 | AAK1 (0.42) | AAK1ABL1IRAK4BRD4BRAF | |
| SCHEMBL17653080 | 0.74 | AAK1 (0.51) | AAK1SLC10A2 | |
| SCHEMBL17653204 | 0.74 | AAK1 (0.67) | AAK1 | |
| SCHEMBL17653387 | 0.72 | AAK1 (0.51) | AAK1SLC10A2 | |
| SCHEMBL17653226 | 0.72 | AAK1 (0.51) | AAK1SLC10A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200797-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016053794-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-07 | — | — | WO | disclosed |