Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 15/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653173 | 0.85 | AAK1 (0.51) | AAK1IMPDH2 | |
| SCHEMBL17653121 | 0.84 | CYP3A4 (0.34) | AAK1 | |
| SCHEMBL17653097 | 0.82 | APP (0.35) | AAK1 | |
| SCHEMBL17653193 | 0.82 | AAK1 (0.36) | AAK1 | |
| SCHEMBL17653305 | 0.81 | AAK1 (0.50) | AAK1IMPDH2GPR119 | |
| SCHEMBL17653133 | 0.79 | AAK1 (0.42) | AAK1 | |
| SCHEMBL17653229 | 0.79 | AAK1 (0.52) | AAK1GPR119 | |
| SCHEMBL17653227 | 0.78 | AAK1 (0.51) | AAK1IMPDH2 | |
| SCHEMBL17653184 | 0.76 | AAK1 (0.53) | AAK1IMPDH2 | |
| SCHEMBL17653108 | 0.76 | AAK1 (0.49) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200797-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016053794-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-07 | — | — | WO | disclosed |