Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 3/20 | 0.42 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655412 | 0.89 | FGFR4 (0.46) | FGFR4GPR52CNR2CA2CA9 | |
| SCHEMBL12959030 | 0.84 | FGFR4 (0.45) | FGFR4GPR52CNR2CA2CA9 | |
| SCHEMBL12805950 | 0.84 | FGFR4 (0.45) | FGFR4GPR52CNR2CA2CA9 | |
| SCHEMBL12805953 | 0.84 | FGFR4 (0.45) | FGFR4GPR52CNR2CA2CA9 | |
| SCHEMBL12653771 | 0.81 | FGFR4 (0.54) | FGFR4CNR2CA2CA9GPR142 | |
| SCHEMBL1817583 | 0.80 | FGFR4 (0.43) | FGFR4CNR2CA2CA9GPR142 | |
| SCHEMBL1817581 | 0.80 | FGFR4 (0.43) | FGFR4CNR2CA2CA9GPR142 | |
| SCHEMBL12654380 | 0.78 | FGFR4 (0.52) | FGFR4CNR2CA2CA9GPR142 | |
| SCHEMBL12958958 | 0.78 | CNR2 (0.46) | FGFR4CNR2EPHX2TDP1SCN9A | |
| SCHEMBL12654402 | 0.77 | FGFR4 (0.46) | FGFR4CNR2CA2CA9GPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493888-B1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-04-06 | — | — | EP | disclosed |