Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.81 |
| ▸ | JAK2 | O60674 | 1/20 | 0.79 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.68 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450050 | 0.90 | LRRK2 (1.00) | LRRK2JAK2 | |
| SCHEMBL7450262 | 0.88 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2 | |
| SCHEMBL7451347 | 0.86 | LRRK2 (0.86) | LRRK2JAK2 | |
| SCHEMBL7454399 | 0.86 | LRRK2 (0.86) | LRRK2JAK2MAP3K9MKNK2 | |
| SCHEMBL7449811 | 0.85 | LRRK2 (1.00) | LRRK2JAK2 | |
| SCHEMBL9280006 | 0.84 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2 | |
| SCHEMBL14556225 | 0.83 | LRRK2 (0.94) | LRRK2JAK2 | |
| SCHEMBL14641949 | 0.83 | LRRK2 (0.82) | LRRK2JAK2MAP3K9MKNK2 | |
| SCHEMBL7459229 | 0.83 | LRRK2 (1.00) | LRRK2MAP3K9MKNK2 | |
| SCHEMBL12066134 | 0.83 | LRRK2 (1.00) | LRRK2JAK2MAP3K9MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576541-B1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | HOFFMANN LA ROCHE (CH) | 2016-04-06 | — | — | EP | disclosed |