Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.65 |
| ▸ | PARP1 | P09874 | 5/20 | 0.42 |
| ▸ | CDC7 | O00311 | 8/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.41 |
| ▸ | CDK2 | P24941 | 8/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 8/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 2/20 | 0.38 |
| ▸ | DAPK1 | P53355 | 2/20 | 0.38 |
| ▸ | DMPK | Q09013 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12053448 | 0.89 | SCN10A (0.67) | SCN10APARP1NPC1RAB9AAAK1 | |
| SCHEMBL17656273 | 0.89 | SCN10A (0.54) | SCN10APARP1CDC7CCNE1CDK2 | |
| SCHEMBL16907913 | 0.86 | SCN10A (0.64) | SCN10APARP1NPC1RAB9AAAK1 | |
| SCHEMBL1293368 | 0.86 | SCN10A (0.64) | SCN10APARP1NPC1RAB9AAAK1 | |
| SCHEMBL1293364 | 0.86 | SCN10A (0.64) | SCN10APARP1NPC1RAB9AAAK1 | |
| SCHEMBL12798837 | 0.85 | SCN10A (0.63) | SCN10APARP1CDC7CCNE1CDK2 | |
| SCHEMBL1293406 | 0.85 | SCN10A (0.63) | SCN10APARP1NPC1RAB9AAAK1 | |
| SCHEMBL1293405 | 0.85 | SCN10A (0.63) | SCN10APARP1NPC1RAB9AAAK1 | |
| SCHEMBL19385241 | 0.84 | SCN10A (0.62) | SCN10APARP1AAK1USP30 | |
| SCHEMBL19385240 | 0.84 | SCN10A (0.62) | SCN10APARP1AAK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002281-B1 | ANTIVIRAL COMPOUNDS | GILEAD PHARMASSET LLC (US) | 2017-09-13 | — | — | EP | disclosed |
| EP-3002281-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2016-04-06 | — | — | EP | disclosed |