Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 20/20 | 0.91 |
| ▸ | HCRTR1 | O43613 | 19/20 | 0.91 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1671364 | 0.95 | HCRTR2 (1.00) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL27883278 | 0.85 | HCRTR2 (0.78) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL1671102 | 0.85 | HCRTR2 (1.00) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL1673082 | 0.84 | HCRTR1 (1.00) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL1673037 | 0.84 | HCRTR1 (1.00) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL18912825 | 0.80 | HCRTR2 (0.69) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL1671252 | 0.80 | HCRTR1 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL18910764 | 0.79 | HCRTR2 (0.71) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL18910848 | 0.79 | HCRTR2 (0.79) | HCRTR2HCRTR1KCNH2 | |
| SCHEMBL1671407 | 0.79 | HCRTR1 (1.00) | HCRTR2HCRTR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3093291-A1 | DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C]PYRROLES AS OREXIN RECEPTOR MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2016-11-16 | — | — | EP | disclosed |
| EP-2491038-B1 | DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C]PYRROLES AS OREXIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-04-06 | — | — | EP | disclosed |