Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 18/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17030524 | 1.00 | CFTR (0.57) | CFTRHDAC1HTR2APDE4DSCN5A | |
| SCHEMBL1466279 | 0.91 | CFTR (0.64) | CFTRHDAC1HTR2APDE4DSCN5A | |
| SCHEMBL12741404 | 0.91 | CFTR (0.64) | CFTRHDAC1HTR2APDE4DSCN5A | |
| SCHEMBL12741802 | 0.91 | CFTR (0.64) | CFTRHDAC1HTR2APDE4DSCN5A | |
| SCHEMBL17030516 | 0.91 | CFTR (0.63) | CFTRHDAC1HTR2APDE4DSCN5A | |
| SCHEMBL17656337 | 0.89 | CFTR (0.54) | CFTRHTR2APDE4DSCN5A | |
| SCHEMBL17030591 | 0.88 | CFTR (0.56) | CFTRHDAC1HTR2APDE4DSCN5A | |
| SCHEMBL12741391 | 0.88 | CFTR (0.54) | CFTRHDAC1KDM4EL3MBTL1 | |
| SCHEMBL14403600 | 0.87 | CFTR (0.73) | CFTRHDAC1HTR2APDE4DSCN5A | |
| SCHEMBL17656341 | 0.87 | CFTR (0.55) | CFTRHDAC1HTR2APDE4DSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2674428-B1 | Modulators of ATP-binding cassette transporters | VERTEX PHARMA (US) | 2016-04-06 | — | — | EP | disclosed |