Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784890 | 0.89 | FLT1 (0.44) | FLT1KDRFLT3TRPA1HDAC6 | |
| SCHEMBL17703745 | 0.86 | HDAC6 (0.46) | TRPA1HDAC6AOC3BCL2L1DRD2 | |
| SCHEMBL17656757 | 0.84 | AOC3 (0.48) | HDAC6AOC3BCL2L1DRD2DRD4 | |
| SCHEMBL12526352 | 0.84 | AOC3 (0.47) | HDAC6AOC3BCL2L1DRD2DRD4 | |
| SCHEMBL16784924 | 0.83 | AOC3 (0.45) | FLT1KDRFLT3TRPA1HDAC6 | |
| SCHEMBL12526638 | 0.83 | AOC3 (0.49) | HDAC6AOC3BCL2L1DRD2DRD4 | |
| SCHEMBL16785024 | 0.81 | AOC3 (0.48) | FLT1KDRFLT3HDAC6AOC3 | |
| SCHEMBL17703740 | 0.74 | AOC3 (0.55) | AOC3BCL2L1DRD2DRD4DRD3 | |
| SCHEMBL16785169 | 0.73 | AOC3 (0.50) | HDAC6AOC3BCL2L1DRD2DRD4 | |
| SCHEMBL16784922 | 0.72 | AOC3 (0.49) | HDAC6AOC3CHRM3ROCK2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002278-A1 | GUANIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-06 | — | — | EP | disclosed |