Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 14/20 | 0.58 |
| ▸ | AXL | P30530 | 4/20 | 0.43 |
| ▸ | MERTK | Q12866 | 4/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273971 | 0.90 | CHRM1 (0.71) | CHRM1 | |
| SCHEMBL12803313 | 0.82 | CHRM1 (0.73) | CHRM1 | |
| SCHEMBL2226588 | 0.79 | CHRM1 (0.74) | CHRM1 | |
| SCHEMBL6890030 | 0.77 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL12803383 | 0.77 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL12802497 | 0.76 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL12802494 | 0.76 | CHRM1 (0.43) | CHRM1 | |
| SCHEMBL2272502 | 0.75 | CHRM1 (0.66) | CHRM1 | |
| SCHEMBL17656781 | 0.75 | CHRM1 (0.45) | CHRM1GRM2 | |
| SCHEMBL21545709 | 0.74 | CHRM1 (0.79) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-B1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-04-06 | — | — | EP | disclosed |