Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.53 |
| ▸ | BTK | Q06187 | 16/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17646014 | 0.87 | EPHX2 (0.58) | EPHX2NR1H4BTK | |
| SCHEMBL17660343 | 0.84 | BTK (0.40) | BTK | |
| SCHEMBL30950456 | 0.84 | BTK (0.40) | BTK | |
| SCHEMBL30950537 | 0.83 | BTK (0.61) | BTK | |
| SCHEMBL15678744 | 0.75 | EPHX2 (0.58) | EPHX2NR1H4BTK | |
| SCHEMBL15678703 | 0.74 | BTK (0.56) | EPHX2NR1H4BTK | |
| SCHEMBL30950458 | 0.73 | BTK (0.52) | BTK | |
| SCHEMBL15678702 | 0.73 | BTK (0.54) | EPHX2NR1H4BTK | |
| SCHEMBL30950478 | 0.73 | BTK (0.50) | EPHX2NR1H4BTK | |
| SCHEMBL17645973 | 0.72 | BTK (0.65) | EPHX2NR1H4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016057500-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-04-14 | — | — | WO | disclosed |
| US-20160096834-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-04-07 | — | — | US | disclosed |
| US-20160096834-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160096834-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | BTK, SYK, LYN | EPHX2 1940/4885NR1H4 3566/4885BTK 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.