Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 14/20 | 0.71 |
| ▸ | CD38 | P28907 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368081 | 0.90 | IRAK4 (0.69) | IRAK4CD38EGFRMAP4K4 | |
| SCHEMBL17663382 | 0.86 | IRAK4 (0.76) | IRAK4 | |
| SCHEMBL17653577 | 0.83 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL4357479 | 0.83 | IRAK4 (0.75) | IRAK4CD38EGFRMAP4K4 | |
| SCHEMBL22368046 | 0.82 | IRAK4 (0.72) | IRAK4CD38EGFRMAP4K4 | |
| SCHEMBL17656917 | 0.82 | IRAK4 (0.76) | IRAK4 | |
| SCHEMBL4353446 | 0.81 | IRAK4 (0.77) | IRAK4CD38EGFRMAP4K4 | |
| SCHEMBL22368022 | 0.81 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL17653567 | 0.81 | IRAK4 (1.00) | IRAK4 | |
| SCHEMBL17653569 | 0.81 | IRAK4 (1.00) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200790-B1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2020-08-26 | — | — | EP | disclosed |
| WO-2016053770-A1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2016-04-07 | — | — | WO | disclosed |