SCHEMBL1766384

SCHEMBL1766384

O=C(Nc1cccc(C(=O)Nc2c(I)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)c1)c1ccc(F)cc1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.50
KMT2A Q03164 6/20 0.50
KCNK3 O14649 4/20 0.50
KCNK9 Q9NPC2 2/20 0.50
MAPT P10636 3/20 0.47
RAB9A P51151 2/20 0.47
NPC1 O15118 2/20 0.47
LMNA P02545 1/20 0.47
PTGES O14684 1/20 0.46
CES1 P23141 2/20 0.45
PTGS1 P23219 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1767397 0.95 KCNK3 (0.47) MEN1KMT2AKCNK3KCNK9MAPT
SCHEMBL1767276 0.93 MEN1 (0.50) MEN1KMT2AKCNK3KCNK9MAPT
SCHEMBL1766911 0.93 KCNK3 (0.55) MEN1KMT2AKCNK3KCNK9MAPT
SCHEMBL29409945 0.93 KCNK3 (0.55) MEN1KMT2AKCNK3KCNK9MAPT
SCHEMBL1766400 0.89 MAPT (0.46) MEN1KMT2AKCNK3KCNK9MAPT
SCHEMBL1766266 0.88 RXFP1 (0.52) MEN1KMT2AKCNK3KCNK9MAPT
SCHEMBL1766422 0.88 MEN1 (0.47) MEN1KMT2AKCNK3KCNK9MAPT
SCHEMBL1766741 0.88 F2R (0.45) MEN1KMT2AKCNK3KCNK9MAPT
SCHEMBL1766591 0.88 PPARG (0.44) KCNK3KCNK9MAPTRAB9ALMNA
SCHEMBL1767005 0.88 KCNK3 (0.52) MEN1KMT2AKCNK3KCNK9MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2023-07-20 US disclosed
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MITSUI CHEMICALS AGRO, INC. (JP) 2023-07-11 US disclosed
EP-3081552-B1 PEST CONTROL AGENT CONTAINING AN AMIDE DERIVATIVE AND USE OF THE PEST CONTROL AGENT MITSUI CHEMICALS AGRO INC (JP) 2021-03-03 EP disclosed
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2020-09-10 US disclosed
US-10582708-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2020-03-10 US disclosed
WO-2019059412-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2019-03-28 WO disclosed
US-20170367329-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2017-12-28 US disclosed
US-9756856-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2017-09-12 US disclosed
EP-2319830-B1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE PEST CONTROL AGENT MITSUI CHEMICALS AGRO INC (JP) 2016-11-02 EP disclosed
EP-3081552-A1 PEST CONTROL AGENT CONTAINING AN AMIDE DERIVATIVE AND USE OF THE PEST CONTROL AGENT Mitsui Chemicals Agro, Inc. (JP) 2016-10-19 EP disclosed
US-9237745-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2016-01-19 US disclosed
US-20130310459-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2013-11-21 US disclosed
US-20130231392-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS ARGO, INC. (JP) 2013-09-05 US disclosed
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-08-18 US disclosed
CN-102119143-A Amide derivative, pest control agent containing the same, and method of using the pest control agent MITSUI CHEMICALS AGRO INC 2011-07-06 CN disclosed
EP-2319830-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND USE OF THE PEST CONTROL AGENT Mitsui Chemicals Agro, Inc. (JP) 2011-05-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MTX1, ENPP1, CAT MEN1 686/4885KMT2A 2306/4885KCNK3 2461/4885
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT MEN1 686/4885KMT2A 2306/4885KCNK3 2461/4885
US-10582708-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative H1-2, H1-4, H1-0 MEN1 3163/4885KMT2A 333/4885KCNK3 350/4885
US-20170367329-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-4, H1-0 MEN1 3163/4885KMT2A 333/4885KCNK3 350/4885
US-20130310459-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-0, H1-4 MEN1 3310/4885KMT2A 262/4885KCNK3 454/4885
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-4, H1-0 MEN1 3163/4885KMT2A 333/4885KCNK3 350/4885
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT MEN1 686/4885KMT2A 2306/4885KCNK3 2461/4885
US-20130231392-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-0, H1-4 MEN1 3310/4885KMT2A 262/4885KCNK3 454/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.