Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 20/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17665873 | 0.84 | MAP4K4 (0.73) | MAP4K4 | |
| SCHEMBL15587570 | 0.82 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL15587569 | 0.81 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL17665820 | 0.81 | MAP4K4 (0.64) | MAP4K4 | |
| SCHEMBL17665801 | 0.79 | MAP4K4 (0.66) | MAP4K4 | |
| SCHEMBL5491630 | 0.78 | MAP4K4 (0.77) | MAP4K4 | |
| SCHEMBL15587454 | 0.78 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL12928160 | 0.78 | MAP4K4 (0.78) | MAP4K4 | |
| SCHEMBL19398215 | 0.78 | MAP4K4 (0.68) | MAP4K4 | |
| SCHEMBL15587451 | 0.77 | MAP4K4 (1.00) | MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200787-B1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2019-09-04 | — | — | EP | disclosed |
| WO-2016053771-A1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2016-04-07 | — | — | WO | disclosed |