Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16011956 | 0.88 | HCRTR1 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16797398 | 0.88 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16198393 | 0.84 | HCRTR2 (0.72) | HCRTR2HCRTR1 | |
| SCHEMBL15826046 | 0.84 | HCRTR2 (0.85) | HCRTR2HCRTR1 | |
| SCHEMBL19222324 | 0.83 | HCRTR2 (0.77) | HCRTR2HCRTR1 | |
| SCHEMBL2290643 | 0.83 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL7914524 | 0.83 | HCRTR2 (1.00) | HCRTR2HCRTR1 | |
| SCHEMBL16198268 | 0.82 | HCRTR2 (0.70) | HCRTR2HCRTR1 | |
| SCHEMBL17876884 | 0.82 | HCRTR2 (0.77) | HCRTR2HCRTR1 | |
| SCHEMBL16198149 | 0.82 | HCRTR2 (0.70) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160102073-A1 | 2-HYDROXYMETHYL-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102073-A1 | 2-HYDROXYMETHYL-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, CRHR2 | HCRTR2 1/4885HCRTR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.