Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17645799 | 0.91 | BTK (0.56) | BTKLCK | |
| SCHEMBL27453384 | 0.90 | BTK (0.58) | BTKLCK | |
| SCHEMBL30950515 | 0.90 | BTK (0.58) | BTKLCK | |
| SCHEMBL27453501 | 0.89 | BTK (0.56) | BTKLCK | |
| SCHEMBL27466048 | 0.89 | BTK (0.60) | BTKLCK | |
| SCHEMBL17670768 | 0.89 | BTK (0.57) | BTKLCK | |
| SCHEMBL30950501 | 0.88 | BTK (0.57) | BTKLCK | |
| SCHEMBL27460049 | 0.88 | BTK (0.57) | BTKLCK | |
| SCHEMBL17645839 | 0.88 | BTK (0.60) | BTKLCK | |
| SCHEMBL30950460 | 0.88 | BTK (0.60) | BTKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204382-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | Merck Patent GmbH (DE) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016057500-A1 | HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-04-14 | — | — | WO | disclosed |