Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17672153 | 0.94 | HDAC1 (0.42) | ROCK1ROCK2HDAC1HDAC2HDAC8 | |
| SCHEMBL17671974 | 0.93 | ROCK1 (0.44) | ROCK1ROCK2HDAC1HDAC2HDAC8 | |
| SCHEMBL16147569 | 0.93 | ROCK1 (0.46) | ROCK1ROCK2HDAC1HDAC2HDAC8 | |
| SCHEMBL17671401 | 0.92 | PPARD (0.47) | ROCK1ROCK2PPARD | |
| SCHEMBL17672043 | 0.91 | HDAC1 (0.42) | ROCK1ROCK2HDAC1HDAC2HDAC8 | |
| SCHEMBL17671849 | 0.91 | HDAC1 (0.52) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL17671738 | 0.88 | HDAC1 (0.45) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL17671566 | 0.87 | HDAC1 (0.46) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| SCHEMBL19213389 | 0.86 | PPARD (0.49) | ROCK1ROCK2PPARD | |
| SCHEMBL17671437 | 0.85 | PPARD (0.47) | ROCK1ROCK2PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016057322-A1 | PPAR AGONISTS AND METHODS OF USE THEREOF | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-04-14 | — | — | WO | claimed |
| WO-2016057322-A1 | PPAR AGONISTS AND METHODS OF USE THEREOF | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2016-04-14 | — | — | WO | disclosed |