Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.75 |
| ▸ | BTK | Q06187 | 11/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.73 |
| ▸ | TEC | P42680 | 1/20 | 0.73 |
| ▸ | TXK | P42681 | 1/20 | 0.73 |
| ▸ | BLK | P51451 | 1/20 | 0.73 |
| ▸ | BMX | P51813 | 1/20 | 0.73 |
| ▸ | JAK3 | P52333 | 1/20 | 0.73 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.73 |
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675591 | 0.89 | EGFR (0.79) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675352 | 0.88 | EGFR (0.74) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675479 | 0.87 | EGFR (0.79) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675514 | 0.86 | BTK (0.78) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675364 | 0.86 | BTK (1.00) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675400 | 0.85 | EGFR (0.76) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17683708 | 0.85 | BTK (0.76) | EGFRBTKERBB2TECTXK | |
| Trifluoroacetic Acid SCHEMBL17675212 | 0.85 | EGFR (0.89) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675390 | 0.84 | EGFR (1.00) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675241 | 0.84 | EGFR (0.67) | EGFRBTKERBB2TECTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | claimed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |