Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 1.00 |
| ▸ | BTK | Q06187 | 4/20 | 1.00 |
| ▸ | FYN | P06241 | 8/20 | 0.72 |
| ▸ | SRC | P12931 | 8/20 | 0.72 |
| ▸ | VCP | P55072 | 1/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.65 |
| ▸ | BLK | P51451 | 1/20 | 0.61 |
| ▸ | BMX | P51813 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675435 | 0.92 | EGFR (0.84) | EGFRBTKFYNSRCVCP | |
| SCHEMBL17675227 | 0.85 | EGFR (0.75) | EGFRBTKFYNSRCVCP | |
| SCHEMBL17675188 | 0.85 | EGFR (0.74) | EGFRBTKFYNSRCERBB2 | |
| SCHEMBL31060509 | 0.84 | FYN (1.00) | EGFRBTKFYNSRCVCP | |
| SCHEMBL614989 | 0.84 | FYN (1.00) | EGFRBTKFYNSRCVCP | |
| SCHEMBL17675434 | 0.84 | EGFR (1.00) | EGFRBTKFYNSRCVCP | |
| SCHEMBL17675257 | 0.84 | EGFR (0.72) | EGFRBTKSRCERBB2ERBB4 | |
| SCHEMBL7239048 | 0.84 | FYN (0.85) | EGFRBTKFYNSRCVCP | |
| SCHEMBL17683823 | 0.84 | EGFR (0.72) | EGFRBTKFYNSRCERBB2 | |
| SCHEMBL17675186 | 0.81 | EGFR (0.68) | EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | claimed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |