Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | FLT3 | P36888 | 7/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23657475 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2FLT3LMNAMAPTNPC1 | |
| SCHEMBL11105052 | 0.87 | FLT3 (0.78) | SMN1; SMN2FLT3LMNAMAPTNPC1 | |
| SCHEMBL15426982 | 0.83 | NPC1 (0.70) | SMN1; SMN2FLT3LMNAMAPTNPC1 | |
| SCHEMBL2943933 | 0.81 | MAPK14 (0.78) | FLT3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL15427119 | 0.81 | FLT3 (0.80) | SMN1; SMN2FLT3LMNAMAPTNPC1 | |
| SCHEMBL4480256 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2FLT3LMNAMAPTNPC1 | |
| SCHEMBL590144 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2FLT3LMNAMAPTNPC1 | |
| SCHEMBL13234696 | 0.79 | FLT3 (0.80) | FLT3MAPTNPC1RAB9AHTT | |
| SCHEMBL13234840 | 0.79 | FLT3 (0.80) | FLT3MAPTNPC1RAB9AHTT | |
| SCHEMBL13200780 | 0.79 | FLT3 (0.63) | SMN1; SMN2FLT3NPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |