Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.60 |
| ▸ | BTK | Q06187 | 8/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.53 |
| ▸ | TEC | P42680 | 1/20 | 0.53 |
| ▸ | TXK | P42681 | 1/20 | 0.53 |
| ▸ | BLK | P51451 | 1/20 | 0.53 |
| ▸ | BMX | P51813 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.43 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.43 |
| ▸ | DNMT3L | Q9UJW3 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675586 | 0.89 | EGFR (0.62) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675249 | 0.87 | BTK (0.80) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675507 | 0.83 | EGFR (0.65) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17683792 | 0.81 | EGFR (0.66) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675509 | 0.81 | EGFR (0.74) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675250 | 0.81 | BTK (0.78) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675292 | 0.81 | DNMT1 (0.56) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17675206 | 0.77 | BTK (0.58) | EGFRBTKERBB2ERBB4USP2 | |
| SCHEMBL17675595 | 0.77 | BTK (0.82) | EGFRBTKERBB2TECTXK | |
| SCHEMBL17683767 | 0.77 | BTK (0.77) | EGFRBTKERBB2TECTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | claimed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |