Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 15/20 | 1.00 |
| ▸ | TEC | P42680 | 2/20 | 1.00 |
| ▸ | TXK | P42681 | 2/20 | 1.00 |
| ▸ | BLK | P51451 | 2/20 | 1.00 |
| ▸ | BMX | P51813 | 2/20 | 1.00 |
| ▸ | ERBB4 | Q15303 | 2/20 | 1.00 |
| ▸ | EGFR | P00533 | 12/20 | 0.81 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.77 |
| ▸ | JAK3 | P52333 | 1/20 | 0.77 |
| ▸ | ITK | Q08881 | 1/20 | 0.77 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675481 | 0.97 | BTK (0.93) | BTKTECTXKBLKBMX | |
| SCHEMBL17675383 | 0.94 | BTK (0.88) | BTKTECTXKBLKBMX | |
| SCHEMBL17675226 | 0.93 | BTK (0.93) | BTKTECTXKBLKBMX | |
| SCHEMBL17675604 | 0.93 | BTK (0.87) | BTKTECTXKBLKBMX | |
| SCHEMBL17675222 | 0.92 | BTK (0.85) | BTKTECTXKBLKBMX | |
| SCHEMBL17675547 | 0.91 | BTK (0.84) | BTKTECTXKBLKBMX | |
| SCHEMBL17675330 | 0.90 | BTK (0.91) | BTKTECTXKBLKBMX | |
| SCHEMBL17675608 | 0.90 | BTK (0.82) | BTKTECTXKBLKBMX | |
| SCHEMBL17675215 | 0.90 | BTK (1.00) | BTKTECTXKBLKBMX | |
| SCHEMBL17675326 | 0.90 | BTK (0.90) | BTKTECTXKBLKBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | claimed |
| WO-2016055982-A1 | QUINOLINE AND QUINAZOLINE COMPOUNDS | ACERTA PHARMA B.V. (NL) | 2016-04-14 | — | — | WO | disclosed |