Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 19/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 16/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 16/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1767943 | 0.86 | MTOR (0.51) | MTORRPTORMLST8PIK3CACSF1R | |
| Cc-115 SCHEMBL135765 | 0.84 | MTOR (0.72) | MTORRPTORMLST8PIK3CACSF1R | |
| Cc-115 SCHEMBL29522125 | 0.84 | MTOR (0.72) | MTORRPTORMLST8PIK3CACSF1R | |
| Cc-115 SCHEMBL1767621 | 0.83 | MTOR (0.71) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL16186757 | 0.77 | MTOR (0.57) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL138204 | 0.76 | MTOR (0.74) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL29522183 | 0.76 | MTOR (0.74) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL138359 | 0.75 | MTOR (0.55) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL136142 | 0.73 | MTOR (0.75) | MTORRPTORMLST8PIK3CACSF1R | |
| SCHEMBL29522078 | 0.73 | MTOR (0.75) | MTORRPTORMLST8PIK3CACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493472-A1 | METHODS OF SYNTHESIS AND PURIFICATION OF HETEROARYL COMPOUNDS | Signal Pharmaceuticals, LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011053518-A1 | METHODS OF SYNTHESIS AND PURIFICATION OF HETEROARYL COMPOUNDS | SIGNAL PHARMACEUTICALS, LLC (US) | 2011-05-05 | — | — | WO | disclosed |