Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.34 |
| ▸ | MPL | P40238 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17296630 | 0.86 | BRAF (0.37) | BRAFNR1I2FBP1 | |
| SCHEMBL17684952 | 0.84 | BRAF (0.31) | BRAF | |
| SCHEMBL17684953 | 0.84 | BRAF (0.31) | BRAF | |
| SCHEMBL17296632 | 0.82 | BRAF (0.35) | BRAFNR1I2 | |
| SCHEMBL574938 | 0.79 | NPC1 (0.36) | — | |
| SCHEMBL574448 | 0.79 | KDM4E (0.36) | — | |
| SCHEMBL15198328 | 0.78 | BRAF (0.32) | BRAF | |
| SCHEMBL574870 | 0.77 | MEN1 (0.32) | — | |
| SCHEMBL575025 | 0.77 | AKT1 (0.32) | — | |
| SCHEMBL15191973 | 0.76 | BRAF (0.42) | BRAFNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2678336-B1 | THIAZOLYLPHENYL-BENZENESULFONAMIDO DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-04-20 | — | — | EP | disclosed |