Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 9/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14998315 | 0.93 | KCNH2 (0.47) | KCNH2ROCK2SLC6A9CASP1GSK3B | |
| SCHEMBL2562548 | 0.93 | KCNH2 (0.47) | KCNH2ROCK2SLC6A9CASP1GSK3B | |
| SCHEMBL16524257 | 0.92 | KCNH2 (0.43) | KCNH2SLC6A9KAT6A | |
| SCHEMBL14998262 | 0.92 | KCNH2 (0.43) | KCNH2SLC6A9KAT6A | |
| SCHEMBL14998436 | 0.90 | KCNH2 (0.45) | KCNH2ROCK2GSK3BMAPTHTT | |
| SCHEMBL16524171 | 0.90 | KCNH2 (0.45) | KCNH2ROCK2GSK3BMAPTHTT | |
| SCHEMBL14998268 | 0.90 | KCNH2 (0.41) | KCNH2SLC6A9KAT6AMTOR | |
| SCHEMBL18470535 | 0.90 | KCNH2 (0.60) | KCNH2SLC6A9CASP1MAPTHTT | |
| SCHEMBL14734717 | 0.90 | KCNH2 (0.51) | KCNH2GSK3BMAPT | |
| SCHEMBL14998231 | 0.90 | KCNH2 (0.51) | KCNH2GSK3BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563365-B1 | CERTAIN AMINO-PYRIDAZINES, COMPOSITIONS THEREOF, AND METHODS OF THEIR USE | CYTOKINETICS INC (US) | 2016-04-20 | — | — | EP | claimed |