Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.35 |
| ▸ | JAK3 | P52333 | 15/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 13/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17685305 | 0.89 | JAK2 (0.35) | JAK2JAK3PTK2TYK2JAK1 | |
| SCHEMBL2144133 | 0.84 | JAK2 (0.39) | JAK2JAK3PTK2TYK2JAK1 | |
| SCHEMBL2145071 | 0.82 | TYK2 (0.42) | JAK2JAK3PTK2TYK2JAK1 | |
| SCHEMBL13504284 | 0.77 | JAK2 (0.54) | JAK2JAK3PTK2TYK2JAK1 | |
| SCHEMBL3301001 | 0.72 | MEN1 (0.36) | JAK2JAK3PTK2TYK2JAK1 | |
| SCHEMBL3300104 | 0.71 | TYK2 (0.37) | JAK2JAK3PTK2TYK2JAK1 | |
| SCHEMBL3303494 | 0.66 | JAK2 (0.50) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144195 | 0.66 | JAK2 (0.40) | JAK2JAK3PTK2TYK2JAK1 | |
| SCHEMBL3860639 | 0.65 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL3301448 | 0.63 | JAK2 (0.44) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |