Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.42 |
| ▸ | JAK3 | P52333 | 14/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 13/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3303800 | 0.91 | JAK2 (0.36) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3303111 | 0.88 | JAK2 (0.35) | JAK2JAK3PTK2EGFRBTK | |
| SCHEMBL17685383 | 0.86 | JAK2 (0.43) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL17685269 | 0.86 | JAK2 (0.41) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL17685344 | 0.84 | JAK2 (0.40) | JAK2JAK3PTK2EGFRBTK | |
| SCHEMBL3303842 | 0.81 | JAK2 (0.37) | JAK2JAK3PTK2 | |
| SCHEMBL3301011 | 0.81 | JAK2 (0.36) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144689 | 0.80 | JAK2 (0.42) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144686 | 0.80 | JAK2 (0.42) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3306749 | 0.80 | JAK3 (0.35) | JAK2JAK3PTK2EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |