Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 16/20 | 0.62 |
| ▸ | JAK3 | P52333 | 12/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.55 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3310284 | 0.94 | JAK2 (0.69) | JAK2JAK3PTK2JAK1PIK3CA | |
| SCHEMBL17685408 | 0.87 | JAK2 (0.57) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2144495 | 0.84 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3305387 | 0.81 | JAK2 (0.52) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2640702 | 0.77 | JAK2 (1.00) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3310278 | 0.77 | JAK2 (0.64) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3302939 | 0.73 | JAK2 (0.71) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL3303547 | 0.73 | JAK2 (0.62) | JAK2JAK3PTK2JAK1 | |
| SCHEMBL2640616 | 0.71 | JAK2 (1.00) | JAK2JAK3PTK2 | |
| SCHEMBL2144170 | 0.71 | JAK2 (0.48) | JAK2JAK3PTK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |