Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 8/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.68 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | TERT | O14746 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
| ▸ | FNTB | P49356 | 1/20 | 0.30 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768182 | 0.78 | CYP2D6 (0.72) | CYP2D6CYP1A2SCN8ACYP3A4SCN1A | |
| SCHEMBL1768304 | 0.77 | ATM (0.43) | CYP2D6CYP1A2SCN8ASCN1ASCN4A | |
| SCHEMBL1768438 | 0.77 | SCN1A (0.59) | CYP2D6CYP1A2SCN8ASCN1ASCN4A | |
| SCHEMBL11896968 | 0.75 | CYP1A2 (0.65) | CYP2D6CYP1A2SCN8ACYP3A4SCN1A | |
| SCHEMBL13583892 | 0.64 | CYP1A2 (0.53) | CYP2D6CYP1A2SCN8ACYP3A4SCN1A | |
| SCHEMBL11896946 | 0.63 | CYP1A2 (0.54) | CYP2D6CYP1A2SCN8ACYP3A4SCN1A | |
| SCHEMBL1768561 | 0.63 | CYP1A2 (0.49) | CYP2D6CYP1A2SCN8ACYP3A4SCN1A | |
| SCHEMBL11896944 | 0.61 | SCN8A (0.53) | CYP2D6CYP1A2SCN8ASCN1ASCN4A | |
| SCHEMBL9257063 | 0.60 | HSD17B10 (0.40) | TAAR1 | |
| SCHEMBL12280938 | 0.59 | CDK2 (0.49) | CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483270-A1 | INDAZOLE DERIVATIVES AND THEIR USE FOR BLOCKADING VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011061469-A1 | INDAZOLE DERIVATIVES AND THEIR USE FOR BLOCKADING VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2011-05-26 | — | — | WO | disclosed |