Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 17/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.47 |
| ▸ | CDK9 | P50750 | 10/20 | 0.47 |
| ▸ | CCNH | P51946 | 10/20 | 0.47 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.47 |
| ▸ | CCNK | O75909 | 4/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 4/20 | 0.43 |
| ▸ | CDK13 | Q14004 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17688399 | 0.89 | CDK7 (0.43) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL19040132 | 0.88 | CDK7 (0.53) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL17141216 | 0.88 | CDK7 (0.53) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL18047349 | 0.88 | CDK7 (0.53) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL16656080 | 0.86 | CDK7 (0.65) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL17688372 | 0.86 | CDK7 (0.65) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL16664893 | 0.86 | CDK2 (0.50) | CDK7CCNT1CDK9CCNHMNAT1 | |
| Hydrochloric Acid SCHEMBL16655196 | 0.86 | CDK7 (0.64) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL16654781 | 0.85 | CDK7 (0.68) | CDK7CCNT1CDK9CCNHMNAT1 | |
| SCHEMBL17688368 | 0.85 | CDK7 (0.50) | CDK7CCNT1CDK9CCNHMNAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057956-B1 | POLYCYCLIC INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA FARBER CANCER INST INC (US) | 2021-05-05 | — | — | EP | disclosed |
| CN-105849099-B | Polycyclic inhibitors of cyclin dependent kinase 7(CDK7) | 达纳-法伯癌症研究所股份有限公司 | 2020-01-17 | — | — | CN | disclosed |
| WO-2016058544-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS, INC. (US) | 2016-04-21 | — | — | WO | disclosed |