Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 20/20 | 0.67 |
| ▸ | JAK1 | P23458 | 12/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15713764 | 0.94 | TYK2 (0.75) | TYK2JAK1KCNH2STAT3 | |
| SCHEMBL29684957 | 0.88 | TYK2 (0.61) | TYK2JAK1KCNH2 | |
| SCHEMBL24497990 | 0.88 | TYK2 (0.61) | TYK2JAK1KCNH2 | |
| SCHEMBL17688916 | 0.87 | TYK2 (0.69) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL17688915 | 0.87 | TYK2 (0.59) | TYK2JAK1CYP2C19KCNH2STAT3 | |
| SCHEMBL18102154 | 0.84 | TYK2 (0.76) | TYK2JAK1CYP2C19STAT3 | |
| SCHEMBL17688914 | 0.83 | TYK2 (0.55) | TYK2JAK1CYP2C19KCNH2STAT3 | |
| SCHEMBL15689431 | 0.82 | TYK2 (0.61) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL15713491 | 0.82 | TYK2 (0.79) | TYK2JAK1KCNH2STAT3 | |
| SCHEMBL15713588 | 0.81 | TYK2 (0.77) | TYK2JAK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9315494-B2 | Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFNα responses | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-19 | — | — | US | disclosed |