Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CDC25A | P30304 | 2/20 | 0.44 |
| ▸ | CDC25B | P30305 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15711353 | 0.83 | APEX1 (0.52) | APEX1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL15711206 | 0.83 | APEX1 (0.52) | APEX1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL20511176 | 0.83 | APEX1 (0.52) | APEX1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL29439993 | 0.83 | APEX1 (0.52) | APEX1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL14135226 | 0.83 | APEX1 (0.52) | APEX1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL14135269 | 0.83 | APEX1 (0.52) | APEX1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL15705618 | 0.82 | APEX1 (0.51) | APEX1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL17834004 | 0.82 | APEX1 (0.51) | APEX1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL14135268 | 0.82 | APEX1 (0.51) | APEX1ALDH1A1MAPTKDM4ETDP1 | |
| SCHEMBL17277147 | 0.81 | APEX1 (0.50) | APEX1ALDH1A1MAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9315481-B2 | Compounds and methods for treating leukemia | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-04-19 | — | — | US | disclosed |
| US-9315481-B2 | Compounds and methods for treating leukemia | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-04-19 | — | — | US | disclosed |